cGMP-compliant production cell line for SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD)
To support COVID-19 research and accelerate the rapid clinical development of your product candidate, trenzyme has developed a cGMP-compliant production cell line for the SARS-CoV-2 Spike S1 (RBD) protein based on the industry leading CHOvolution® CHO-K1 platform (Celonic AG).
After completion of the development process of the production cell line, the high quality research cell bank (RCB) can be transferred to a CDMO (Contract Development and Manufacturing Organization) of your choice for further process development, optimization and high level production.
Our cGMP- compliant Production Cell Line package includes
Several high titer clones available
Full process documentation and certificates
Research Cell Bank (RCB), tested
more than 1 g/L at 1 L scale fed-batch based on CHOvolution® CHO-K1 cell line
Optimized production process, shake flask level (USP)
Optimized downstream purification process (DSP)
Easy transfer to your CDMO partner of choice
Preclinical grade material in lower gram amounts available
Commercially available media
Analytical methods including potency assay (hACE2 binding)
Immunogenicity proven
High Quality - Made in Germany
Overview
| Cell Line / Target Name | CHO-K1 / SARS-CoV-2 Spike S1 Protein (RBD) |
| Catalog No. | C2020-001-127 |
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Target Synonyms |
coronavirus spike protein; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein |
Product Information
| Parental Cell Line | CHO-K1 (23-CHO-S) |
| Platform used | CHOvolution™ (Celonic AG) |
| Product Titer | > 1 g/L (determined by ELISA, shake flask process) |
Additional Information
| The domain of the SARS-CoV-2 Spike S1 (RBD) protein is the most important part of the viral spike protein and responsible for binding of the virus to the human receptor, the ACE-2 protein. Most patients recovered from COVID-19 have developed neutralizing antibodies against this protein, which has been proven by several animal studies. Therefore, it is the preferred target for vaccine development and neutralizing antibody production. |
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SDS-PAGE/Coll. Coomassie |
Histogram of marked lanes in gel picture |
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Fed-batch of final clones |
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Purified Protein (SARS-CoV-2 Spike S1 Protein (RBD)) is available.
Reinhold Horlacher, PhD
Managing Director & CSO
We would be happy to provide you with your desired cell line and to support you on your cell line research project. If you have any questions or requests, our scientific experts will be happy to answer them shortly.
Get In Contact With Our Scientific Experts