Your Reliable Research Service Provider

With more than 20 years of experience as service provider for life science industry, we have a clear mission:

Accelerating your innovation!

Our life science experts together with an outstanding collection of state-of-the-art laboratory equipment and technology enable us to always fulfill our client’s needs at highest quality standards and maximum efficiency, saving you valuable research time and expenses.

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trenzyme about us - company profile

Company Profile

trenzyme GmbH is a privately owned German Contract Research Organization (CRO) offering a wide range of highly customized services in cell line development, iPSC differentiation and recombinant protein production.

Since 2000, trenzyme has been a valued research partner of national and international clients, ranging from academia and small biotechs to big pharmaceutical companies. Our scientific experts are continuously developing new and comprehensive solutions to provide reliable, up-to-date support for the individual and demanding projects of our clients.

Whether your needs lie in the development of assay cell lines, production cell lines, cell expansion, differentiation of human induced pluripotent stem cells or in recombinant protein production, trenzyme’s team is dedicated to delivering the ideal solution for you.

The way we work at trenzyme


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Your benefits from working with us


Since 2000, our highly qualified scientific experts employ their extensive experience to complete your project successfully and efficiently.


Our modular service packages are custom-tailored to your project and allow high flexibility. All services run under ISO9001 quality management standards.


We design project-specific solutions and your project manager keeps you constantly informed throughout the project to ensure maximum success.

trenzyme’s History

Dr. Reinhold Horlacher, Founder, Managing Director & CSO

Reinhold holds a PhD in biology from the University of Konstanz (1996).

After his postdoctoral research in Konstanz and Boston, he was supported by the “Young Innovators” grant from the federal state of Baden-Württemberg (1998 – 2000). During this period at the University of Konstanz, he developed and refined a method for the enzyme based in-vitro synthesis of the disaccharide trehalose. Reinhold founded the company trenzyme in 2000 – the company name is still a reminiscence of this first activity.

Until today, he acts as the managing director and CSO of trenzyme and is always highly motivated to find the ideal solution for the individual requirements of trenzymes clients.

Reinhold Horlacher CEO trenzyme

The milestones of trenzyme


milestones of trenzyme: 1998 - "funding by young innovators"

Funding by “Young Innovators”

milestones of trenzyme: 2000 - foundation of trenzyme gmbh at the university of konstanz

Foundation of trenzyme GmbH at the University of Konstanz Start with Molecular Biology & E.coli Expression Service

milestone of trenzyme: 2002 - protein expression in yeast systems

Protein Expression in yeast systems

milestones of trenzyme: 2004 - cell line development in cooperation with partners

Cell Line Development in cooperation with partners

milestone of trenzyme: 2007 - move to own building on nycomed campus | cooperation agreement with nycomed

Move to own building on Nycomed campus | Cooperation agreement with Nycomed

milestone of trenzyme: 2008 - cell line development and in-house service | introduction of our propietary ExoIN System

Cell Line Development ans in-house service | Introduction of our propietary ExoIN System

milestone of trenyme: 2009 - introduction of QMS ISO-certification | massive expansion of cell culture department

Introduction of QMS ISO-certification | Massive expansion of Cell Culture Department

milestone of trenzyme: 2011 - introduction of professional & systematic data management with LIMS (laboratory integrated management software)

Introduction of professional & systematic data management with LIMS (laboratory integrated management software)

milestone of trenzyme: 2012 - launch of new logo & corporate design

Launch of new logo & Corporate Design

milestone of trenzyme: 2013 - move to another building with more lab space on the konstanz campus

Move to another building with more lab space on the Konstanz Campus

milestone of trenzyme: 2014 - expansion of the protein service portfolio | introduction of guaranteed protein packages

Expansion of the Protein Service Portfolio | Introduction of Guaranteed Protein Packages

milestone of trenzyme: 2015 - introduction of GMP-compliant production cell line service | 15th anniversary

Introduction of GMP-compliant Production Cell Line Service | 15th anniversary

milestone of trenzyme: 2017 - launch of new website | introduction of iPSC cell services

Launch of new Website | Introduction of iPSC Cell Services

milestoene of trenzyme: 2019 - implementation of advanced cell services as a new department

Implementation of Advanced Cell Services as a new department

milestone of trenzyme: 2020 - implementation of recombinant SARS-CoV-2 proteins as catalog proteins | vaccine development XPOVAX & patent application vaccine platform | 20th anniversary

Implementation of recombinant SARS-CoV-2 Proteins as Catalog Proteins | Vaccine Development XPOVAX & Patent Application Vaccine Platform | 20th anniversary

trenzyme scientist at work

trenzyme’s Mission

As full service provider for the life science industry, we have a clear mission:

Accelerating your innovation!

Our life science experts together with an outstanding collection of state-of-the-art laboratory equipment and technology enable us to always fulfill our client’s needs at highest quality standards and maximum efficiency, saving you valuable research time and expenses.

What clients say about us

We highly appreciate the collaboration with trenzyme on account of the following reasons: trenzyme provides high quality material and services. The ‘outstanding’ team gives excellent advices, is skilled and professional. Direct and uncomplicated communication was possible at all times.

Dr. Roland Lange Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland
clients logo idorsia

We have expanded and tested the clonal cell lines and we are extremely happy with their performance. Needless to mention, that it was possible because the process of generation of cell lines at Trenzyme was very efficient and robust. I would definitely be interested in getting the engineered cell lines from Trenzyme in the future, if the need arises.

Dr. Harish Pai Biocon Research Center, Bangalore, India
clients logo biocon

trenzyme is one of our preferred service providers for cell line development and molecular biology services. The impressive level of personal customer liaison and the scientific competence are decisive factors for us to cooperate with trenzyme for many years and even to intensify in the area of demanding iPS cell line projects.

Dr. Margit Bauer & Dr. Ralf Heilker Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany
clients logo Boehringer Ingelheim

Due to the outstanding flexibility to address our particular project needs as well as the excellent quality of the provided services, trenzyme is one of our preferred service providers for many years.

Dr. Steffen Schaffer Evonik Creavis GmbH, Marl, Germany

No need to take the pipet in hand while relying on trenzyme!

Prof. Dr. Roger Clerc F. Hoffmann – La Roche Ltd, Basel, Switzerland
clients logo roche trenzyme

It was a pleasure to work with trenzyme. Our expectations were fully met. trenzyme’s team of professional scientific experts helped us to complete our objectives in time. We were also pleased with the quality of the documentation provided. In a nutshell, I can recommend trenzyme as a reliable service provider.

Michael Samassa Celonic AG, Basel, Switzerland
clients logo celonic trenzyme

We appreciated trenzyme’s very open communication throughout the project and the detailed documentation provided. We are really happy with the outcome and would absolutely come to trenzyme again in the future for any custom proteins. Thank you to the whole team for their skills and effort in a good result, it is very exciting for us to be able to work with this material!

Prof. Dr. Shana J. Sturla ETH-Zurich, Department of Health Sciences and Technology, Zurich, Switzerland
clients logo ETH Zürich trenzyme

We highly valued the fast and excellent communication and the high flexibility of the team! For any future project, we will preferably entrust in trenzyme’s protein production services.

Dr. Thore Hettmann Probiodrug AG, Halle/Saale, Germany
clients logo probiodrug trenzyme

We were astonished by trenzyme’s recently delivered custom ExoIN cell lines. Even “difficult-to-express” constructs show stable and robust expression. I highly recommend trenzyme’s cell line development service.

PD Dr. Dieter Wicher Max Planck Institute for Chemical Ecology, Jena, Germany
clients logo max planck institute for chemical ecology trenzyme

Our GMP-compliant production cell line development project was performed professionally and qualitatively. We thank trenzyme for the good collaboration and hope for future projects.

Dr. Aleksandr Piskunov Generium Pharmaceuticals
clients logo generium pharmaceutical

Quick turn around time.

Dr. Linda Knirsch Takeda (formerly Nycomed), Konstanz, Germany
clients logo takeda

We have been entrusting trenzyme for over a year with protein production and purification projects from various host organisms such as mammalian cells and E.coli. Throughout the entire collaboration, trenzyme has been a reliable, flexible, and innovative outsourcing partner. I particularly appreciate trenzyme’s scientific competence and their proactive communication during our collaboration, and I certainly hope that we will continue this collaboration in the years to come.

Dr. Christiane Smerling 3B Pharmaceuticals GmbH, Berlin, Germany
clients logo 3b pharmaceuticals

In our COVID-19 projects, we have had very good experience with the SARS-CoV-2 proteins produced by trenzyme: rapid and reliable production of the functional proteins from different cell lines continued to provide first-class support for our projects.

Dr. Peter Rauch CANDOR Bioscience GmbH, Wangen, Germany
clients logo candor - the elisa experts

We are happy that trenzyme is such an experienced partner who complements our antibody generation service with their excellent protein production skills.

Dr. Dagmar Schwertner-Knoll BioGenes GmbH, Berlin, Germany
clients logo biogenes