Recombinant SARS-CoV-2 Proteins
To support COVID-19 research, we produce ready-to-use recombinant SARS-CoV-2 proteins which can be used as antigen for analytic and immunodiagnostic purposes as well as for vaccine development.
One of the most important SARS-CoV-2 proteins for coronavirus research is the surface membrane protein Spike Glycoprotein (S). It is known to mediate the entry of the virus into human respiratory epithelial cells by interacting with the human cell surface receptor Angiotensin Converting Enzyme 2 (ACE-2).
The Spike S protein of SARS-CoV-2, the receptor binding domain (RBD) of SARS-CoV-2 Spike S1 protein and the human ACE-2 protein are crucial targets in COVID-19 research for the development of therapeutic antibodies, vaccines and serological tests. In addition, other structural and non-structural SARS-CoV-2 proteins play a relevant role in COVID-19 infection like the SARS-CoV-2 Proteinase 3 CL-Mpro (controlling the activities of the coronavirus replication complex), the SARS-CoV-2 M protein (defining the shape of the virus) and the Nucleocapsid (N) protein (important for viral replication).
Our R&D is continuously working with high priority on producing further relevant recombinant SARS-CoV-2 proteins for COVID-19 research. Due to optimized production process, we also offer bulk quantities up to gram scale.
If you want to discuss your planned COVID-19 research project directly with our scientific experts or if you have any customized inquiries or suggestions for SARS-CoV-2 related protein development, please do not hesitate to contact us.
Catalog of Recombinant SARS-CoV-2 Proteins
Our catalog of ready-to-use SARS-CoV-2 (COVID-19) proteins comprises SARS-COV-2 S, S1 RBD, N, M, 3CL-Mpro and other relevant proteins that are associated with Coronavirus infection. All proteins can be ordered from stock and have very short delivery times.
| Protein Name | Expression Host | Formulation | Price | Product Information | Availability |
|---|---|---|---|---|---|
| SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD) | human, HEK293 | liquid | 100µg: 300€; more on request |  |  Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD) | human, HEK293 | lyophilized | 100µg: 300€; more on request | | Shipped next working day |
| SARS-CoV-2 (COVID 19) Spike S1 Protein (RBD), tag-removed | human, HEK293 | liquid | 100µg: 690€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, short version), His-Tag | human, HEK293 | liquid | 100µg: 300€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD), tag-free | CHO | liquid | 100µg: 290€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD), GFP/His-tag | human, HEK293 | liquid | 100µg: 690€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) S protein, His-Tag, stabilized trimer | human, HEK293 | liquid | 100µg: 790€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) S Protein, stabilized trimer, tag-removed | human, HEK293 | liquid | 100µg: 1390€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) S protein, GFP/His-Tag, trimer | human, HEK293 | liquid | 100µg: 1390€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) Nucleocapsid protein, His-Tag | E. coli | liquid | 100µg: 420€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) 3CL-Mpro Protein, His-Tag | E. coli | liquid | 100µg: 390€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) 3CL-Mpro Protein, Tag-free | E. coli | liquid | 100µg: 440€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 (COVID-19) 3CL-Mpro Protein, unmodified | E. coli | liquid | 100µg: 490€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 M Protein, GFP/His-tagged | human, HEK293-F | liquid | 50µg: 780€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 E Protein, GFP/His-tag | E. coli | liquid | 100µg: 350€; more on request | | Shipped next working day, depending on destination |
| Human ACE2 Protein (ECD, processed), Tag-free | human, HEK293 | liquid | 100µg: 690€; more on request | | Shipped next working day, depending on destination |
| Human ACE2 Protein (ECD, processed), Tag-free | human, HEK293 | lyophilized | 100µg: 690€; more on request | | Shipped next working day |
| Biotinylated Human ACE2 Protein (ECD), Avi/His-Tag | human, HEK293 | liquid | 100µg: 890€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 Spike S1 Protein (RBD, Mutant (N439K)) | human, HEK293 | liquid | 100µg: 470€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 Spike S1 Protein (RBD, Mutant (Y453F)) | human, HEK293 | liquid | 100µg: 470€; more on request | | Shipped next working day, depending on destination |
| SARS-CoV-2 Spike S1 Protein (RBD, Mutant (N501Y)) | human, HEK293 | liquid | on request |  |
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| SARS-CoV-2 (COVID-19) Spike S protein (ECD), Fc-Tag | human, HEK293 | liquid | on request | |
Further off-the-shelf recombinant proteins
Learn more about our other off-the-shelf recombinant proteins in our continuously growing catalog.
Background to the new Coronavirus SARS-CoV-2
The spread of the 2019 new Coronavirus (SARS-CoV-2) throughout the world has a strong impact on our daily life and the fight against COVID-19 is one of the most important tasks of the scientific world in these days.
The new Coronavirus (SARS-CoV-2) belongs to a group of enveloped positive-stranded RNA viruses that consist of four structural proteins including spike (S) glycoprotein, envelope (E) protein, membrane (M) protein and nucleocapsid (N) protein.
As the most important surface protein of SARS-CoV-2, the Spike glycoprotein can mediate the infection of human respiratory epithelial cells by binding the cell surface receptor angiotensin-converting enzyme 2 (ACE2).
Fig.1: Protein structure of new Coronavirus (SARS-CoV-2): Spike (S) Glycoprotein, Envelope protein (E), Membrane protein (M) and Nucleocapsid protein (N)
Reinhold Horlacher, PhD
Managing Director & CSO
We would be happy to provide you with support on your protein research project. Let us know your questions and requests, our scientific experts will reply shortly.
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