Protein Production and Purification Services

Our experienced scientific specialists provide high quality recombinant protein expression and purification services tailored to your specific needs. Whether you are interested in standard recombinant protein production or in highly customized solutions for your challenging target, we are dedicated to providing the ideal service strategy for your research project and to delivering high quality proteins to accelerate your innovation.

Protein Production and Purification

We offer a one-stop-shop for your individual target: from gene synthesis and cloning to high quality purification. All we need to start production and purification of your recombinant proteins is your target sequence. Our scientific experts have a vast knowledge on all current expression platforms, including bacteria, yeast, insect and mammalian cells, based on our longstanding experience.

Individual consulting and a free feasibility analysis for every project ensure that we follow the best strategy to produce your target protein. We at trenzyme set great value in high quality work, reliability and transparency. Our dedicated project management and our scientific experts will be in close communication with you to ensure a successful project progression and to react with high flexibility to your individual demands. We look forward to working with you.

“We highly valued the fast and excellent communication and the high flexibility of the team! For any future project we will preferably entrust in trenzyme’s protein production services.”

Dr. Thore Hettmann

Probiodrug AG, Halle/Saale, Germany

Guaranteed Expression Packages

All-inclusive standardized service package from cloning to purification. Guaranteed yield, purity and timeline – pay only when we succeed!

Custom Protein Production

Highly flexible and tailored services for your specific project needs of recombinant protein production and purification

Expression Screening

Find the perfect expression system for your target – screening of your target protein expression in different expression hosts are possible

High-Yield Protein Production

Protein production [mg-g] scale – 
We deliver your target protein in the desired amount with the highest quality!

Relevant Publications

Growth hormone isoform-differential mass spectrometry for doping control purposes. Drug Test. Anal. 10, 938–946. (2018)

Arsene C, Schulze D, Röthke A, Thevis M, and Henrion A

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Protein phosphatase V ensures timely cell cycle remodeling during the mid-blastula transition in Drosophila. bioRxiv 172379. (2017)

Liu B, Sung H, Gregor I, Müller A, and Grosshans J

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An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejana. J. Biol. Chem. 289, 15130–15140. (2014)

Juneja P, Horlacher R, Bertrand D, Krause R, Marger F, and Welte W

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Role of periplasmic trehalase in uptake of trehalose by the thermophilic bacterium Rhodothermus marinus. J. Bacteriol. 190, 1871–1878. (2008)

Jorge CD, Fonseca LL, Boos W, and Santos H

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A highly thermostable trehalase from the thermophilic bacterium Rhodothermus marinus. Extrem. Life Extreme Cond. 11, 115–122. (2007)

Jorge CD, Sampaio MM, Hreggvidsson GO, Kristjánson JK, and Santos H

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The high-affinity maltose/trehalose ABC transporter in the extremely thermophilic bacterium Thermus thermophilus HB27 also recognizes sucrose and palatinose. J. Bacteriol. 187, 1210–1218. (2005)

Silva Z, Sampaio M-M, Henne A, Böhm A, Gutzat R, Boos W, da Costa MS, and Santos H

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The crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in Corynebacterineae. J. Biol. Chem. 280, 26573–26585. (2005)

Tropis M, Meniche X, Wolf A, Gebhardt H, Strelkov S, Chami M, Schomburg D, Krämer R, Morbach S, and Daffé M

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TreT, a novel trehalose glycosyltransferring synthase of the hyperthermophilic archaeon Thermococcus litoralis. J. Biol. Chem. 279, 47890–47897. (2004)

Qu Q, Lee S-J, and Boos W

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The YadA protein of Yersinia pseudotuberculosis mediates high-efficiency uptake into human cells under environmental conditions in which invasin is repressed. Infect. Immun. 70, 4880–4891. (2002)

Eitel J, and Dersch P

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Protein Services FAQs

How many custom proteins have you produced so far? What is the typical success rate?

We are working on recombinant proteins for more than 20 years and we have successfully produced more than 1000 different proteins so far. The generall success rate is over 80%.

What is the concentration range of your proteins? How do you determine the quantity of them?

The concentration is mostly between 0.1 and 2 mg/ml but can be adjusted according to your needs. The concentration will be determined by either BCA, adsorption at 280nm or densitometric determination after Coomassie staining.

Can tags be cleaved off from recombinant proteins?

Yes, in most cases we use cleavable tag sequences. But cleavage efficiency can be influenced by the target protein and has to be tested.

Reinhold Horlacher, PhD

Reinhold Horlacher, PhD

Managing Director & CSO

We would be happy to provide you with support on your protein research project. Use our contact form to let us know your questions and requests regarding our protein services, our scientific experts will reply shortly.

Get In Contact With Our Scientific Experts

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