Recombinant Protein Expression Service in Yeast

With our Recombinant Protein Expression Service in Yeast, our experienced protein experts provide a reliable platform for the efficient expression of recombinant proteins in yeast cells. We specialize in the use of yeast systems of Saccharomyces cerevisiae and Pichia pastoris (now also known as Komagataella phaffii) for high-yield recombinant protein production.

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Service for Recombinant Protein Expression in Yeast_trenzyme GmbH

Recombinant Protein Expression in Yeast

Highly Customized Service

To accelerate your project, we offer a highly customized recombinant protein expression service in yeast. Our state-of-the-art facilities are designed to support upscaling to fermentation production, ensuring a seamless transition from small-scale experiments to large-scale production. We achieve high cell density fermentation, which is critical for maximizing productivity and efficiency in protein synthesis. Our protein experts have developed proprietary techniques to enhance the expression of the target protein and to facilitate the protein secretion process. This allows easy purification of the target protein from the supernatant, improving yields and significantly reducing downstream processing costs.

With our robust yeast expression systems, our customers can expect consistent, high quality recombinant proteins suitable for a wide range of applications including therapeutic, research and industrial enzymes.

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Efficient Platform For Recombinant Protein Expression in Yeast

Pichia pastoris

  • Pichia pastoris is known for its excellent protein folding and secretion capabilities, with minimal endogenous secretory proteins, making it an ideal choice for straightforward large scale production and establishment of an efficient purification processes.

Saccharomyces cerevisiae

  • Saccharomyces cerevisiae: its well-characterised genome and rapid growth in well-defined media allow the establishment of scalable fermentation processes with high cell density and productivity.

    Process of

    Recombinant Protein Expression in Yeast

    Recombinant-Protein-Expression-in-Yeast_Process-Steps_trenzyme-GmbH

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    Protein Expression Service in Yeast

    Package Includes

    • Process development including detailed and complete documentation available
    • Delivery of test samples from pilot scale expression and upscaling steps possible to check for activity and quality
    • Comprehensive datasheet
    • Standard Quality Control: SDS-PAGE, purity and concentration determination. Additional analytics on request

    Recombinant Protein Expression Service in Yeast

    Your Benefits

    Recombinant Protein Expression in Yeast_Icon Robust Expression System

    Robust Yeast Systems For Efficient Target Expression

    We are offering cutting-edge protein production services utilizing the robust yeast systems of Pichia pastoris (Komagataella phaffii) and Saccharomyces cerevisiae.

    bioreactor_Icon_state-of-the-art-facilities-at-trenzyme_expression-in-yeast

    State-Of-The-Art Facilities

    Our state-of-the-art facilities are designed to support the upscaling to fermentation manufacturing, ensuring a seamless transition from small-scale experiments to large-scale production.

    Service-Icon_Maximized-Success_Expression-Service_trenzyme-GmbH

    Maximized Success

    Highly sophisticated screening process across multiple target variants and constructs to maximize success rate.

    Recombinant Protein Expression in Yeast_Icon for Efficient Technology

    Efficient Proprietary Techniques

    Our expert team has developed proprietary techniques to enhance target protein expression and to facilitate the protein secretion process. This allows the straightforward purification of the target protein from supernatant by improving the yield and significantly reducing downstream processing costs.

    Recombinant-Protein-Expression-Service_Icon for easy-project-start

    Simple Project Start

    We only need to know the sequence of your desired protein to start with. The project starts with codon and DNA structure optimized gene synthesis followed by subcloning into expression constructs from our large collection of expression backbones.

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    Upscaling & High Yield Production

    After initial testing in small and pilot scale experiments, we scale up the expression to bioreactor processes to deliver the protein quantity you are looking for. High Yield Production: Set-up of fed-batch production processes with a high cell density

    What Our Clients Say About Us

    It was a pleasure to work with trenzyme. Our expectations were fully met. trenzyme’s team of professional scientific experts helped us to complete our objectives in time. We were also pleased with the quality of the documentation provided. In a nutshell, I can recommend trenzyme as a reliable service provider.

    Michael Samassa Celonic AG, Basel, Switzerland
    clients logo celonic trenzyme
    Reinhold Horlacher CEO trenzyme
    Reinhold Horlacher, PhD
    Managing Director & CSO

    We would be happy to provide you with support on your protein research project. Let us know your questions and requests, our scientific experts will reply shortly.

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    With Our Scientific Experts

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