SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, short version), His-Tag

Recombinant protein of the receptor binding domain (RBD, short version) of SARS-CoV-2 (COVID-2019) Spike S1 from Wuhan pneumonia virus with C-terminal His-Tag.

Order Details

  • 100µg – 300€
  • more on request – bulk and gram quantities available

Shipped next working day, depending on destination

Overview

Product Name SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, short version), His-Tag
Catalog No. P2020-026
RefSeq Links NC_045512.2; MN908947.3; YP_009724390.1; QHD43416.1; GeneID: 43740568; UniProt: P0DTC2
Synonyms SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein; 2019-nCoV; COVID-2019; COVID-19

Sequence Information

Species SARS-CoV-2; Wuhan seafood market pneumonia virus
Tags His-tag, C-terminal
Sequence without tags (AA 330-532) PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLY
NSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDF
TGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY
FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTN

 

Product Information

Expression Host human, HEK293
Formulation PBS, pH 7,4
Format Liquid, stored and shipped at -80°C
Purity > 90% as determined by SDS-PAGE

Background Information

The spike (S) glycoprotein of coronaviruses is essential for binding of the virus to the host cell at the beginning of the infection process. The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein is responsible for membrane fusion and is therefore required for virus entry and cell fusion. The target protein is also a major immunogen and a possible target for entry inhibitors.
The SARS-CoV-2 spike (S) protein is a large type I transmembrane protein composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) responsible for binding to the host cell receptor angiotensin-converting enzyme 2 (ACE2). The S2 subunit mediates fusion between the viral and host cell membranes. The S1 RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

SDS-PAGE/Coll. Coomassie

Histogram of marked lane in gel picture

SDS-PAGE/Coll.Coomassie of SARS-CoV-2 Spike S1 (RBD,short) Histogram (of marked lane in gel picture) of SARS-CoV-2 Spike S1(RBD,short) Protein

Activity of SARS-CoV-2 S1(RBD, short)

Graphic showing activity of SARS-CoV-2 S1(RBD, short
Activity of SARS-CoV-2 S1(RBD, short) was determined using a Sandwich-ELISA with antibodies from Sino Biological Europe GmbH (coat: #40150-D003 and detection: #40150-D001-H). SARS-CoV-2 S1(RBD, short) amount was reduced to compensate for its smaller MW.

Further recombinant SARS-CoV-2 proteins

Learn more about our other recombinant SARS-CoV-2 proteins.
Reinhold Horlacher, PhD

Reinhold Horlacher, PhD

Managing Director & CSO

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