SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, short version), His-Tag
Recombinant protein of the receptor binding domain (RBD, short version) of SARS-CoV-2 (COVID-2019) Spike S1 from Wuhan pneumonia virus with C-terminal His-Tag.
Order Details
- 100µg – 300€
- more on request – bulk and gram quantities available
Shipped next working day, depending on destination
Overview
| Product Name | SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, short version), His-Tag |
| Catalog No. | P2020-026 |
| RefSeq Links | NC_045512.2; MN908947.3; YP_009724390.1; QHD43416.1; GeneID: 43740568; UniProt: P0DTC2 |
| Synonyms | SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein; 2019-nCoV; COVID-2019; COVID-19 |
Sequence Information
| Species | SARS-CoV-2; Wuhan seafood market pneumonia virus |
| Tags | His-tag, C-terminal |
| Sequence without tags (AA 330-532) | PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLY NSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDF TGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTN |
Product Information
| Expression Host | human, HEK293 |
| Formulation | PBS, pH 7,4 |
| Format | Liquid, stored and shipped at -80°C |
| Purity | > 90% as determined by SDS-PAGE |
Background Information
| The spike (S) glycoprotein of coronaviruses is essential for binding of the virus to the host cell at the beginning of the infection process. The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein is responsible for membrane fusion and is therefore required for virus entry and cell fusion. The target protein is also a major immunogen and a possible target for entry inhibitors. The SARS-CoV-2 spike (S) protein is a large type I transmembrane protein composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) responsible for binding to the host cell receptor angiotensin-converting enzyme 2 (ACE2). The S2 subunit mediates fusion between the viral and host cell membranes. The S1 RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. |
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SDS-PAGE/Coll. Coomassie |
Histogram of marked lane in gel picture |
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Activity of SARS-CoV-2 S1(RBD, short) |
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| Activity of SARS-CoV-2 S1(RBD, short) was determined using a Sandwich-ELISA with antibodies from Sino Biological Europe GmbH (coat: #40150-D003 and detection: #40150-D001-H). SARS-CoV-2 S1(RBD, short) amount was reduced to compensate for its smaller MW. |
Further recombinant SARS-CoV-2 proteins
Learn more about our other recombinant SARS-CoV-2 proteins.
Reinhold Horlacher, PhD
Managing Director & CSO
We would be happy to provide you with your desired protein and to support you on your protein research project. If you have any questions or requests, our scientific experts will be happy to answer them shortly.
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