SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, Mutant (N501Y))
Recombinant protein of the receptor binding domain (RBD), mutant (N501Y) of SARS-CoV-2 (COVID-2019) Spike S1 from Wuhan pneumonia virus with C-terminal His-Tag.
|Product Name||SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD, Mutant (N501Y))|
|RefSeq Links||NC_045512.2; MN908947.3; YP_009724390.1; QHD43416.1; GeneID: 43740568; UniProt: P0DTC2|
|Synonyms||SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein; 2019-nCoV; COVID-2019; COVID-19; RBD (N501Y); 501.V2; VUI-202012/01; B.1.1.7; B117|
|Species||SARS-CoV-2; Wuhan seafood market pneumonia virus|
|Sequence without tags (AA 319-541)||RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYA
|Expression Host||human, HEK293|
|Formulation||PBS, pH 7,4|
|Format||Liquid, stored and shipped at -80°C|
|The spike (S) glycoprotein of coronaviruses is essential for binding of the virus to the host cell at the beginning of the infection process. The target protein is also a major immunogen and a possible target for entry inhibitors.
The SARS-CoV-2 spike (S) protein is a large type I transmembrane protein composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) responsible for binding to the host cell receptor angiotensin-converting enzyme 2 (ACE2). Several mutants of the spike protein are known. A new SARS-CoV-2 lineage called 501Y.V2, also known as lineage B.1.1.7, exhibits several mutations. Compared to the previously circulating variants, the mutation N501Y of line B.1.1.7 results in approximately 70% higher transmissibility. This increase is most likely due to a higher binding affinity of the spike protein to hACE2. Therefore, the N501Y mutation is considered the most dangerous modification of the virus.
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Reinhold Horlacher, PhD
Managing Director & CSO
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