SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD), tag-free
Recombinant protein of the receptor binding domain (RBD) of SARS-CoV-2 (COVID-2019) Spike S1 from Wuhan pneumonia virus, no affinity tags or other artificial sequences present.
Order Details
- 100µg – 290 €
- more on request – bulk and gram quantities available
Shipped next working day, depending on destination
Preclinical Version available on request: includes additional QC and more data
Overview
| Product Name | SARS-CoV-2 (COVID 19) Spike S1 Protein (RBD), tag-free |
| Catalog No. | P2020-022 |
| RefSeq Links | NC_045512.2; MN908947.3; YP_009724390.1; QHD43416.1; GeneID: 43740568; UniProt: P0DTC2 |
| Synonyms | SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein; 2019-nCoV; COVID-2019; COVID-19 |
| Product Information |  |
Sequence Information
| Species | SARS-CoV-2; Wuhan seafood market pneumonia virus |
| Tags | tag-free |
| Sequence without tags (AA 319-541) | RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYA DSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAG STPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF |
Product Information
| Expression Host | CHO |
| Formulation | PBS, pH 7,4 |
| Format | Liquid, stored and shipped at -80°C |
| Purity | > 90% as determined by SDS-PAGE |
Background Information
| The spike (S) glycoprotein of coronaviruses is essential for binding of the virus to the host cell at the beginning of the infection process. The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein is responsible for membrane fusion and is therefore required for virus entry and cell fusion. The target protein is also a major immunogen and a possible target for entry inhibitors. The SARS-CoV-2 spike (S) protein is a large type I transmembrane protein composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) responsible for binding to the host cell receptor angiotensin-converting enzyme 2 (ACE2). The S2 subunit mediates fusion between the viral and host cell membranes. The S1 RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. |
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SDS-PAGE/Coll. Coomassie |
Histogram of marked lane in gel picture |
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Further recombinant SARS-CoV-2 proteins
Learn more about our other recombinant SARS-CoV-2 proteins.
Reinhold Horlacher, PhD
Managing Director & CSO
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