SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD), tag-free
Recombinant protein of the receptor binding domain (RBD) of SARS-CoV-2 (COVID-2019) Spike S1 from Wuhan pneumonia virus, no affinity tags or other artificial sequences present.
- 100µg – 290 €
- more on request – bulk and gram quantities available
Shipped next working day, depending on destination
Preclinical Version available on request: includes additional QC and more data
|Species||SARS-CoV-2; Wuhan seafood market pneumonia virus|
|Sequence without tags (AA 319-541)||RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYA
|Formulation||PBS, pH 7,4|
|Format||Liquid, stored and shipped at -80°C|
|Purity||> 90% as determined by SDS-PAGE|
|The spike (S) glycoprotein of coronaviruses is essential for binding of the virus to the host cell at the beginning of the infection process. The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein is responsible for membrane fusion and is therefore required for virus entry and cell fusion. The target protein is also a major immunogen and a possible target for entry inhibitors.
The SARS-CoV-2 spike (S) protein is a large type I transmembrane protein composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) responsible for binding to the host cell receptor angiotensin-converting enzyme 2 (ACE2). The S2 subunit mediates fusion between the viral and host cell membranes. The S1 RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Further recombinant SARS-CoV-2 proteins
Reinhold Horlacher, PhD
Managing Director & CSO