hACE2 Protein (ECD, processed), Tag-free, lyophilized formulation

The human Angiotensin-Converting Enzyme 2 (ACE-2) is a protein highly expressed at the surface of cells of the human lungs, arteries, kidney, heart and intestine and is shown to be the entry receptor for SARS-CoV-2 infection. The ACE-2 protein is one of the most important components for Coronavirus research to develop effective therapies for COVID-19.

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  • 100µg – 590€
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Product Name hACE2 Protein (ECD, processed), Tag-free, lyophilized formulation
Catalog No. P2020-024
RefSeq Links UniProt: Q9BYF1
Synonyms hACE2; ACEH; human angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; Metalloprotease MPROT15
Product Information

Sequence Information

Species Homo sapiens, human
Tags tag-free

Product Information

Expression Host human, HEK293
Formulation 50 mM Tris, 250 mM NaCl, pH 8,0
Format Lyophilized and shipped at room temperature
Purity > 80% as determined by SDS-PAGE

Background Information

The human Angiotensin-Converting Enzyme 2 (hACE-2) is a type I transmembrane metallocarboxypeptidase with homology to ACE, an regulator in the Renin-Angiotensin system (RAS) and long-known as a target for the treatment of hypertension.

hACE2 is expressed at the surface of cells of the human lungs, arteries, kidneys, heart and intestine – all tissues shown to harbor SARS-CoV. The function of ACE-2 is known as controlling blood pressure. This is accomplished by the hydrolysis of a small peptide hormone called Angiotensin II into the nonapeptide Angiotensin 1-9, which is thereafter converted into the heptapeptide angiotensin 1-7 by ACE and other endopeptidases. Angiotensin 1-7 acts in a vasoconstricting manner and is believed to be one of the main effectors in controlling the blood pressure and is therefore involved in pathophysiological processes like diabetes, hypertension and cardiac function in general. Recently it became known, that the new Coronavirus SARS-CoV-2 uses ACE-2 as the entry point into alveolar cells of the lungs, where it replicates and causes the Coronavirus disease (COVID-19).​

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Reinhold Horlacher, PhD

Reinhold Horlacher, PhD

Managing Director & CSO

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